Article
beta4GalT-II increases cisplatin-induced apoptosis in HeLa cells depending on its Golgi localization.
Biochemical and biophysical research communications - 22 Jun 2007
Jiang Jianhai, Zhou Jin, Wei Yuanyan, Shen Jialin, Liu Dan, Chen Xiaoning, Zhang Si, Kong Xiangfei, Yun Xiaojing, Gu Jianxin
Abstract excerpt
beta1,4-Galactosyltransferase II (beta4GalT-II) is one of the enzymes transferring galactose to the terminal N-acetylglucosamine of complex-type N-glycans and its expression is significantly altered during oncogenesis with unknown functions. Here, we reported for the first time the pro-apoptotic role of beta4GalT-II in tumor cells. The level of beta4GalT-II mRNA expression was obviously decreased during HeLa cell...
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