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Article

Defects in cell spreading and ERK1/2 activation in fibroblasts with lamin A/C mutations.

Biochimica et biophysica acta - 1 Aug 2009

Emerson Lindsay J, Holt Mark R, Wheeler Matthew A, Wehnert Manfred, Parsons Maddy, Ellis Juliet A

Abstract excerpt

In-frame mutations in nuclear lamin A/C lead to a multitude of tissue-specific degenerative diseases known as the 'laminopathies'. Previous studies have demonstrated that lamin A/C-null mouse fibroblasts have defects in cell polarisation, suggesting a role for lamin A/C in nucleo-cytoskeletal-cell surface cross-talk. However, this has not been examined in patient fibroblasts expressing modified forms of lamin...

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Identifiers

PMID: 19524666
DOI: 10.1016/j.bbadis.2009.05.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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