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Inhibition of cell proliferation, migration and invasion by DNAzyme targeting MMP-9 in A549 cells

5 Jun 2009

Abstract excerpt

Matrix metalloproteinases (MMPs) have been regarded as major critical molecules assisting tumor cells during angiogenesis and metastasis. Enhanced expression of matrix metalloproteinase-9 (MMP-9) is associated with human non-small cell lung cancer (NSCLC) invasion and metastasis. DNAzyme is a single-stranded DNA catalyst that can be engineered to bind to its complementary sequence in the target gene and cleave...

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PMID: 19513513
DOI: 10.3892/or_00000414

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