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Article

Influence of MMP-2 and MMP-9 promoter polymorphisms on gene expression and clinical outcome of non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 May 2007

Rollin Jérôme, Régina Sandra, Vourc'h Patrick, Iochmann Sophie, Bléchet Claire, Reverdiau Pascale, Gruel Yves

Abstract excerpt

Matrix metalloproteinases (MMP) including MMP-2 and MMP-9 play a major role in tumour invasion by proteolysing the extracellular matrix. Their activation, particularly that of MMP-9, is partly dependent on plasmin that is inhibited by TFPI-2 (tissue factor pathway inhibitor-2), a serine protease inhibitor whose gene expression is decreased in about one-third of non-small cell lung cancers (NSCLC). In addition,...

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Identifiers

PMID: 17208328
DOI: 10.1016/j.lungcan.2006.11.021

Genes

TFPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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