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Article

Aging and replicative senescence have related effects on human stem and progenitor cells.

PloS one - 9 Jun 2009

Wagner Wolfgang, Bork Simone, Horn Patrick, Krunic Damir, Walenda Thomas, Diehlmann Anke, Benes Vladimir, Blake Jonathon, Huber Franz-Xaver, Eckstein Volker, Boukamp Petra, Ho Anthony D

Abstract excerpt

The regenerative potential diminishes with age and this has been ascribed to functional impairments of adult stem cells. Cells in culture undergo senescence after a certain number of cell divisions whereby the cells enlarge and finally stop proliferation. This observation of replicative senescence has been extrapolated to somatic stem cells in vivo and might reflect the aging process of the whole organism. In...

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Identifiers

PMID: 19513108
DOI: 10.1371/journal.pone.0005846
PMCID: PMC2688074

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MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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