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KCNQ5 and C9orf50 Methylation in Stool DNA for Early Detection of Colorectal Cancer

29 Jan 2021

Abstract excerpt

Background Aberrant DNA methylation has emerged as a class of promising biomarkers for early colorectal cancer (CRC) detection, but the performance of methylated C9orf50 and methylated KCNQ5 in stool DNA has never been evaluated. Methods Methylation specific quantitative PCR (qPCR) assays for methylated C9orf50 and methylated KCNQ5 were developed. The methylation levels of C9orf50 and KCNQ5 in 198 CRC patients,...

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PMID: 33585248
DOI: 10.3389/fonc.2020.621295

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