Article
Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development.
Gut - 1 May 2015
Chia Na-Yu, Deng Niantao, Das Kakoli, Huang Dachuan, Hu Longyu, Zhu Yansong, Lim Kiat Hon, Lee Ming-Hui, Wu Jeanie, Sam Xin Xiu, Tan Gek San, Wan Wei Keat, Yu Willie, Gan Anna, Tan Angie Lay Keng, Tay Su-Ting, Soo Khee Chee, Wong Wai Keong, Dominguez Lourdes Trinidad M, Ng Huck-Hui, Rozen Steve, Goh Liang-Kee, Teh Bin-Tean, Tan Patrick
Abstract excerpt
OBJECTIVE: Gastric cancer (GC) is a deadly malignancy for which new therapeutic strategies are needed. Three transcription factors, KLF5, GATA4 and GATA6, have been previously reported to exhibit genomic amplification in GC. We sought to validate these findings, investigate how these factors function to promote GC, and identify potential treatment strategies for GCs harbouring these amplifications. DESIGN: KLF5,...
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