Experimental expression in mice and spontaneous expression in human SLE of polyomavirus T-antigen. A molecular basis for induction of antibodies to DNA and eukaryotic transcription factors.

Abstract excerpt

We have previously demonstrated that experimental expression of the polyomavirus transcription factor T-antigen has the potential to induce anti-DNA antibodies in mice. Two sets of independent evidences are presented here that demonstrate a biological relevance for this model. First, we describe results demonstrating that mice inoculated with T-antigen-expressing plasmids produced antibodies, not only to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antenna Design and Analysis
• Share to Energy Harvesting in Wireless Networks
• Share to Polyomavirus and related diseases