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Article

Ectodomain shedding of FLT3 ligand is mediated by TNF-alpha converting enzyme.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2009

Horiuchi Keisuke, Morioka Hideo, Takaishi Hironari, Akiyama Haruhiko, Blobel Carl P, Toyama Yoshiaki

Abstract excerpt

FLT3 ligand (FLT3L) has diverse roles in the hematopoietic system, which include stimulating proliferation of hematopoietic precursors and development of NK cells and dendritic cells. FLT3L is initially synthesized as a membrane-bound protein, which must be cleaved to become a soluble growth factor. However, little is known about the enzyme involved in the proteolytic release of FLT3L. In the current study, we...

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Source

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Identifiers

PMID: 19494263
DOI: 10.4049/jimmunol.0801931
PMCID: PMC2921975

Genes

FLT3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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