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Article

Ovine TRIM5α Can Restrict Visna/Maedi Virus

14 Jun 2012

Abstract excerpt

The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ovine TRIM5α effectively restricted the lentivirus visna/maedi virus DNA synthesis. Proteasome inhibition in cells transduced with ovine TRIM5α restored restricted viral DNA synthesis, suggesting a...

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Identifiers

PMID: 22696640
DOI: 10.1128/jvi.00440-12

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