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Article

Targeting Rad50 sensitizes human nasopharyngeal carcinoma cells to radiotherapy.

BMC cancer - 7 Mar 2016

Chang Lihong, Huang Jiancong, Wang Kai, Li Jingjia, Yan Ruicheng, Zhu Ling, Ye Jin, Wu Xifu, Zhuang Shimin, Li Daqing, Zhang Gehua

Abstract excerpt

BACKGROUND: The Mre11-Rad50-Nbs1 (MRN) complex is well known for its crucial role in initiating DNA double strand breaks (DSBs) repair pathways to resistant irradiation (IR) injury and thus facilitating radioresistance which severely reduces radiocurability of nasopharyngeal cancer (NPC). Targeting native cellular MRN function would sensitize NPC cells to IR. METHODS: A recombinant adenovirus containing a mutant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26951044
DOI: 10.1186/s12885-016-2190-8
PMCID: PMC4782334

Genes

RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Targeting Rad50 sensitizes human nasopharyngeal carcinoma cells to radiotherapy.PMID 26951044Read ↗

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