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Article

Hepatitis B virus reverse transcriptase sequence variant database for sequence analysis and mutation discovery.

Antiviral research - 1 Dec 2010

Rhee Soo-Yon, Margeridon-Thermet Severine, Nguyen Mindie H, Liu Tommy F, Kagan Ron M, Beggel Bastian, Verheyen Jens, Kaiser Rolf, Shafer Robert W

Abstract excerpt

Drug resistance resulting from reverse transcriptase (RT) mutations is one of the main obstacles to successful hepatitis B virus (HBV) therapy. Indeed, HBV treatment guidelines recommend HBV genotypic resistance testing for patients receiving nucleos(t)ide RT inhibitors (N(t)RTIs) who develop virological failure. N(t)RTI-resistance mutations at 10 RT positions have been well characterized in phenotypic studies,...

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Identifiers

PMID: 20875460
DOI: 10.1016/j.antiviral.2010.09.012
PMCID: PMC4374605

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