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Article

The C(-1562)T polymorphism of the MMP-9 gene and the risk of sporadic amyotrophic lateral sclerosis.

Neurologia i neurochirurgia polska - 1 Jan 2000

Zawiślak Dorota, Borratyńska Anna, Tomik Barbara, Pera Joanna, Gryz-Kurek Elzbieta, Szczudlik Andrzej

Abstract excerpt

BACKGROUND AND PURPOSE: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of multiple and poorly understood aetiopathogenesis. Genetic factors involved in the pathogenesis of sporadic ALS still remain unknown. A candidate gene might be matrix metalloproteinase-9 gene (MMP-9) - a member of the matrix metalloproteinase family capable of degrading elements of the extracellular matrix. Recent data...

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PMID: 19484688

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