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Article

Pex3p-dependent peroxisomal biogenesis initiates in the endoplasmic reticulum of human fibroblasts.

Journal of cellular biochemistry - 15 Aug 2009

Toro Andrés A, Araya Claudia A, Córdova Gonzalo J, Arredondo Cristian A, Cárdenas Hugo G, Moreno Regina E, Venegas Alejandro, Koenig Cecilia S, Cancino Jorge, Gonzalez Alfonso, Santos Manuel J

Abstract excerpt

The mechanisms of peroxisomal biogenesis remain incompletely understood, specially regarding the role of the endoplasmic reticulum (ER) in human cells, where genetic disorders of peroxisome biogenesis lead to Zellweger syndrome (ZS). The Pex3p peroxisomal membrane protein (PMP) required for early steps of peroxisome biogenesis has been detected in the ER in yeast but not in mammalian cells. Here, we show that...

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Source

Identifiers

PMID: 19479899
DOI: 10.1002/jcb.22210

Genes

PEX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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