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Article

Small interfering RNA targeting m2 gene induces effective and long term inhibition of influenza A virus replication.

PloS one - 22 May 2009

Sui Hong-Yan, Zhao Guang-Yu, Huang Jian-Dong, Jin Dong-Yan, Yuen Kwok-Yung, Zheng Bo-Jian

Abstract excerpt

RNA interference (RNAi) provides a powerful new means to inhibit viral infection specifically. However, the selection of siRNA-resistant viruses is a major concern in the use of RNAi as antiviral therapeutics. In this study, we conducted a lentiviral vector with a H1-short hairpin RNA (shRNA) expression cassette to deliver small interfering RNAs (siRNAs) into mammalian cells. Using this vector that also expresses...

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Source

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Identifiers

PMID: 19479060
DOI: 10.1371/journal.pone.0005671
PMCID: PMC2682565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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