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Article

Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5.

Human gene therapy - 1 Mar 2013

Maier Dawn A, Brennan Andrea L, Jiang Shuguang, Binder-Scholl Gwendolyn K, Lee Gary, Plesa Gabriela, Zheng Zhaohui, Cotte Julio, Carpenito Carmine, Wood Travis, Spratt S Kaye, Ando Dale, Gregory Philip, Holmes Michael C, Perez Elena E, Riley James L, Carroll Richard G, June Carl H, Levine Bruce L

Abstract excerpt

Since HIV requires CD4 and a co-receptor, most commonly C-C chemokine receptor 5 (CCR5), for cellular entry, targeting CCR5 expression is an attractive approach for therapy of HIV infection. Treatment of CD4(+) T cells with zinc-finger protein nucleases (ZFNs) specifically disrupting chemokine receptor CCR5 coding sequences induces resistance to HIV infection in vitro and in vivo. A chimeric Ad5/F35 adenoviral...

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Share to Adenoviruses, Human
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD28 Antigens

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Share to DNA Restriction Enzymes

Share to Receptors, CCR5

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Source

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Identifiers

PMID: 23360514
DOI: 10.1089/hum.2012.172
PMCID: PMC3609630

Genes

CCR5
CD4
CD28

Provenance

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