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Article

Structures of the G81A mutant form of the active chimera of (S)-mandelate dehydrogenase and its complex with two of its substrates.

Acta crystallographica. Section D, Biological crystallography - 1 Jun 2009

Sukumar Narayanasami, Dewanti Asteriani, Merli Angelo, Rossi Gian Luigi, Mitra Bharati, Mathews F Scott

Abstract excerpt

(S)-Mandelate dehydrogenase (MDH) from Pseudomonas putida, a membrane-associated flavoenzyme, catalyzes the oxidation of (S)-mandelate to benzoylformate. Previously, the structure of a catalytically similar chimera, MDH-GOX2, rendered soluble by the replacement of its membrane-binding segment with the corresponding segment of glycolate oxidase (GOX), was determined and found to be highly similar to that of GOX...

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Identifiers

PMID: 19465768
DOI: 10.1107/S0907444909010270
PMCID: PMC2685731

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