Article
Discovery of function in the enolase superfamily: D-mannonate and d-gluconate dehydratases in the D-mannonate dehydratase subgroup.
Biochemistry - 29 Apr 2014
Wichelecki Daniel J, Balthazor Bryan M, Chau Anthony C, Vetting Matthew W, Fedorov Alexander A, Fedorov Elena V, Lukk Tiit, Patskovsky Yury V, Stead Mark B, Hillerich Brandan S, Seidel Ronald D, Almo Steven C, Gerlt John A
Abstract excerpt
The continued increase in the size of the protein sequence databases as a result of advances in genome sequencing technology is overwhelming the ability to perform experimental characterization of function. Consequently, functions are assigned to the vast majority of proteins via automated, homology-based methods, with the result that as many as 50% are incorrectly annotated or unannotated ( Schnoes et al. PLoS...
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