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Article

Developmental aspects of human hepatic drug glucuronidation in young children and adults

1 Feb 2002

Abstract excerpt

BACKGROUND AND AIMS: The liver represents one of the major sites of human glucuronidation. Many therapeutic drugs are substrates for UDP-glucuronosyltransferases (UGT) leading to the formation of usually inactive glucuronides. Hepatic glucuronidation undergoes significant changes during fetal and neonatal development requiring age adapted drug therapy. Regulation of individual UGT genes during hepatic development...

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PMID: 11788570
DOI: 10.1136/gut.50.2.259

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