Article
Polymorphism in COX-2 modifies the inverse association between Helicobacter pylori seropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control study.
BMC gastroenterology - 23 May 2009
Hu Huang-Ming, Kuo Chao-Hung, Lee Chien-Hung, Wu I-Chen, Lee Ka-Wo, Lee Jang-Ming, Goan Yih-Gang, Chou Shah-Hwa, Kao Ein-Long, Wu Ming-Tsang, Wu Deng-Chyang
Abstract excerpt
BACKGROUND: Overexpression of Cyclooxygenase-2 (COX-2) was observed in many types of cancers, including esophageal squamous cell carcinoma (ESCC). One functional SNP, COX-2 -1195G/A, has been reported to mediate susceptibility of ESCC in Chinese populations. In our previous study, the presence of Helicobacter pylori (H. pylori) was found to play a protective role in development of ESCC. The interaction of COX-2...
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