Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Isomerization of the proline in the M2-M3 linker is not required for activation of the human 5-HT3A receptor.

Journal of neurochemistry - 1 Aug 2009

Paulsen Isabelle M, Martin Ian L, Dunn Susan M J

Abstract excerpt

Each subunit of the cation-selective members of the Cys-loop family of ligand-gated ion channels contains a conserved proline residue in the extracellular loop between the second and third transmembrane domains. In the mouse homomeric 5-hydroxytryptamine type 3A (5-HT(3)A) receptor, the effects of substitution of this proline by unnatural amino acids led to the suggestion that trans-cis isomerization of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histidine
Share to Isomerism
Share to Proline

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Subunits

Share to Receptors, Serotonin, 5-HT3

Share to Serotonin

Share to Tryptophan

Share to Xenopus laevis

Source

Identifiers

PMID: 19457066
DOI: 10.1111/j.1471-4159.2009.06180.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Isomerization of the proline in the M2-M3 linker is not required for activation of the human 5-HT3A receptor.PMID 19457066Read ↗

Effects of a mutation in the TM2-TM3 linker region of the glycine receptor alpha1 subunit on gating and allosteric modulation.Semantic proximity Read ↗

Trans-cis switching mechanisms in proline analogues and their relevance for the gating of the 5-HT3 receptor.Semantic proximity Read ↗

The role of tyrosine residues in the extracellular domain of the 5-hydroxytryptamine3 receptor.Semantic proximity Read ↗

Pharmacological and electrophysiological properties of the naturally occurring Pro391Arg variant of the human 5-HT3A receptor.Semantic proximity Read ↗

The extracellular subunit interface of the 5-HT3 receptors: a computational alanine scanning mutagenesis study.Semantic proximity Read ↗

Modular design of Cys-loop ligand-gated ion channels: functional 5-HT3 and GABA rho1 receptors lacking the large cytoplasmic M3M4 loop.Semantic proximity Read ↗

The minimum M3-M4 loop length of neurotransmitter-activated pentameric receptors is critical for the structural integrity of cytoplasmic portals.Semantic proximity Read ↗

A triad of residues is functionally transferrable between 5-HT3 serotonin receptors and nicotinic acetylcholine receptors.Semantic proximity Read ↗

Mutagenesis and molecular modeling reveal the importance of the 5-HT3 receptor F-loop.Semantic proximity Read ↗

Identification of a domain affecting agonist potency of meta-chlorophenylbiguanide in 5-HT3 receptors.Semantic proximity Read ↗

Impact of intracellular domain flexibility upon properties of activated human 5-HT3 receptors.Semantic proximity Read ↗

The loop C region of the murine 5-HT3A receptor contributes to the differential actions of 5-hydroxytryptamine and m-chlorophenylbiguanide.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.