Article
Interleukin 18 promoter variants (-137G>C and -607C>A) in patients with chronic hepatitis C: association with treatment response.
Journal of clinical immunology - 1 Sept 2009
Haas Stephan L, Weiss Christel, Bugert Peter, Gundt Jutta, Witt Heiko, Singer Manfred V, Berg Thomas, Böcker Ulrich
Abstract excerpt
BACKGROUND: Recently, two functional IL18 promoter variants, -607C>A (rs1946518) and -137G>C (rs187238), were associated with viral clearance in patients with hepatitis C. The present study focused on their relevance for treatment response. METHODS: Seven hundred fifty-seven chronically infected European patients and 791 controls were enrolled in the study. IL18 genotyping was performed by allele-specific PCR....
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