Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis.

International journal of cancer - 1 Sept 2009

Lee Chien-Hung, Wu Deng-Chyang, Wu I-Chen, Goan Yih-Gang, Lee Jang-Ming, Chou Shah-Hwa, Chan Te-Fu, Huang Hsiao-Ling, Hung Yu-Hsiu, Huang Meng-Chuan, Lai Tai-Cheng, Wang Tsu-Nai, Lan Cheng-Che E, Tsai Sharon, Lin Wen-Yi, Wu Ming-Tsang

Abstract excerpt

Genetic variants in alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) genes modulate acetaldehyde removal upon alcohol ingestion. Although these genetic vulnerabilities have been linked to higher esophageal squamous cell carcinoma (ESCC) risks, it is unclear whether they also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetaldehyde
Share to Alcohol Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alcohol Drinking

Share to Aldehyde Dehydrogenase

Share to Aldehyde Dehydrogenase, Mitochondrial

Share to Carcinoma, Squamous Cell

Share to Esophageal Neoplasms

Share to Taiwan

Source

Identifiers

PMID: 19449376
DOI: 10.1002/ijc.24357

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19449376-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis.PMID 19449376Read ↗

Alcohol Consumption, ALDH2 Polymorphism as Risk Factors for Upper Aerodigestive Tract Cancer Progression and PrognosisSemantic proximity Read ↗

Clinical features of superficial esophagus squamous cell carcinoma according to alcohol-degrading enzyme ADH1B and ALDH2 genotypes.Semantic proximity Read ↗

Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the consumption of alcohol, tobacco and betel quid.Semantic proximity Read ↗

Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking.Semantic proximity Read ↗

ADH1B-ALDH2 genotype combinations, age-related risk, and field cancerization in head and neck and upper GI cancer screening in 10 073 alcohol-dependent men.Semantic proximity Read ↗

Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal Squamous Cell Cancer RiskSemantic proximity Read ↗

Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.Semantic proximity Read ↗

Relationship between esophageal squamous cell carcinoma risk and alcohol-related ALDH2 and ADH1B polymorphisms: Evidence from a meta-analysis and Mendelian randomization analysis.Semantic proximity Read ↗

Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China.Semantic proximity Read ↗

Alcohol and Head and Neck Cancer: Updates on the Role of Oxidative Stress, Genetic, Epigenetics, Oral Microbiota, Antioxidants, and Alkylating AgentsSemantic proximity Read ↗

ALDH2 dysfunction and alcohol cooperate in cancer stem cell enrichmentSemantic proximity Read ↗

ALDH2 dysfunction accelerates ESCC pathogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.