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Article

Accumulation of TDP-43 and alpha-actin in an amyotrophic lateral sclerosis patient with the K17I ANG mutation.

Acta neuropathologica - 1 Oct 2009

Seilhean Danielle, Cazeneuve Cécile, Thuriès Valérie, Russaouen Odile, Millecamps Stéphanie, Salachas François, Meininger Vincent, Leguern Eric, Duyckaerts Charles

Abstract excerpt

A K17I mutation in the ANG gene encoding angiogenin has been identified in a case that we previously published as ALS with neuronal intranuclear protein inclusions (Seilhean et al. in Acta Neuropathol 108:81-87, 2004). These inclusions were immunoreactive for smooth muscle alpha-actin but not for angiogenin. Moreover, they were not labeled by anti-TDP-43 antibodies, while numerous cytoplasmic inclusions...

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Identifiers

PMID: 19449021
DOI: 10.1007/s00401-009-0545-9

Genes

ANG
FUS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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