Article
Gain-of-function PDGFRA mutations, earlier reported in gastrointestinal stromal tumors, are common in small intestinal inflammatory fibroid polyps. A study of 60 cases.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2009
Lasota Jerzy, Wang Zeng-Feng, Sobin Leslie H, Miettinen Markku
Abstract excerpt
The inflammatory fibroid polyp is a rare benign lesion occurring throughout the digestive tract. It usually forms a solitary mass, characterized by a proliferation of fibrovascular tissue infiltrated by a variable number of inflammatory cells. The etiology of this lesion is unknown and conflicting histogenetic theories have been proposed. Recently, mutations in platelet-derived growth factor receptor (PDGFRA) and...
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