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Article

Activating PDGFRA mutations in inflammatory fibroid polyps occur in exons 12, 14 and 18 and are associated with tumour localization.

Histopathology - 1 Jul 2012

Huss Sebastian, Wardelmann Eva, Goltz Diane, Binot Elke, Hartmann Wolfgang, Merkelbach-Bruse Sabine, Büttner Reinhard, Schildhaus Hans-Ulrich

Abstract excerpt

AIMS: Inflammatory fibroid polyps (IFP) are mesenchymal tumours of the gastrointestinal tract. This study was performed to broaden the base of evidence of the pathogenic role of PDGFR mutations in IFP with particular regard to clinicopathological data and mutational patterns among IFP subtypes. METHODS AND RESULTS: Molecular analysis of 38 tumours revealed activating mutations in three different exons of PDGFRA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrointestinal Stromal Tumors

Share to Gene Expression Regulation, Neoplastic

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Share to Intestinal Polyps

Share to Receptor, Platelet-Derived Growth Factor alpha

Source

Identifiers

PMID: 22394371
DOI: 10.1111/j.1365-2559.2012.04203.x

Genes

PDGFRA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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