Article
Aromatase expression is increased in BRCA1 mutation carriers.
BMC cancer - 16 May 2009
Chand Ashwini L, Simpson Evan R, Clyne Colin D
Abstract excerpt
BACKGROUND: Until recently, the molecular mechanisms explaining increased incidence of ovarian and breast cancers in carriers of BRCA1 gene mutations had not been clearly understood. Of significance is the finding that BRCA1 negatively regulates aromatase expression in vitro. Our objective was to characterise aromatase gene (CYP19A1) and its promoter expression in breast adipose and ovarian tissue in BRCA1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.