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Focal spermatogenesis originates in euploid germ cells in classical Klinefelter patients

14 May 2009

Abstract excerpt

BACKGROUND: Klinefelter syndrome is the most frequent chromosome abnormality in human males. This paper aims to investigate the ploidy of meiotic and pre-meiotic germ cells found in spermatogenic foci, and furthermore, the sex chromosome constitution of Sertoli cells which surround these germ cells in non-mosaic Klinefelter patients. METHODS AND RESULTS: A survey of 11 adult patients diagnosed with classical,...

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Share to Chromosomal and Genetic Variations
Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Sperm and Testicular Function

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PMID: 19443454
DOI: 10.1093/humrep/dep180

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