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Germ cell loss in Klinefelter syndrome: When and why?

15 May 2020

Abstract excerpt

Klinefelter syndrome (KS) is a quite common disorder with an incidence of 1-2 in 1,000 new-born males. Most patients are diagnosed in the light of a clinical checkup when consulting a fertility clinic with an unfulfilled child wish. Infertility in KS patients is caused by a massive germ cell loss, leading to azoospermia in more than 90% of the adult patients. Most seminiferous tubules in the adult KS testis are...

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PMID: 32412180
DOI: 10.1002/ajmg.c.31787

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