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Article

Genetic determination of the effect of post-translational modification on the innate immune response to the 19 kDa lipoprotein of Mycobacterium tuberculosis.

BMC microbiology - 14 May 2009

Wilkinson Katalin A, Newton Sandra M, Stewart Graham R, Martineau Adrian R, Patel Janisha, Sullivan Susan M, Herrmann Jean-Louis, Neyrolles Olivier, Young Douglas B, Wilkinson Robert J

Abstract excerpt

BACKGROUND: The 19 kDa lipoprotein of Mycobacterium tuberculosis (MTB) is an important target of the innate immune response. To investigate the effect of post-translation modification of this protein on innate recognition in the context of the whole bacillus, we derived a recombinant M. tuberculosis H37Rv that lacked the 19 kDa gene (Delta19) and complemented this strain by reintroduction of the 19 kDa gene into...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 19442300
DOI: 10.1186/1471-2180-9-93
PMCID: PMC2689228

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TNF

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