Article
Interference of Mycobacterium tuberculosis cell division by Rv2719c, a cell wall hydrolase.
Molecular microbiology - 1 Oct 2006
Chauhan Ashwini, Lofton Hava, Maloney Erin, Moore Jacob, Fol Marek, Madiraju Murty V V S, Rajagopalan Malini
Abstract excerpt
The genetic factors responsible for the regulation of cell division in Mycobacterium tuberculosis are largely unknown. We showed that exposure of M. tuberculosis to DNA damaging agents, or to cephalexin, or growth of M. tuberculosis in macrophages increased cell length and sharply elevated the expression of Rv2719c, a LexA-controlled gene. Overexpression of Rv2719c in the absence of DNA damage or of antibiotic...
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