Article
Mutations for Gaucher disease confer high susceptibility to Parkinson disease.
Archives of neurology - 1 May 2009
Mitsui Jun, Mizuta Ikuko, Toyoda Atsushi, Ashida Ryo, Takahashi Yuji, Goto Jun, Fukuda Yoko, Date Hidetoshi, Iwata Atsushi, Yamamoto Mitsutoshi, Hattori Nobutaka, Murata Miho, Toda Tatsushi, Tsuji Shoji
Abstract excerpt
BACKGROUND: Increased frequency of pathogenic variants in GBA, the causative gene for Gaucher disease, has been suggested to be associated with Parkinson disease (PD). OBJECTIVES: To conduct comprehensive resequencing of GBA to identify all sequence variants and to investigate the association of these variants with PD. DESIGN: Case-control study. SETTING: Multicenter university-based study. PARTICIPANTS: Five...
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