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Article

Structural insights into CUG repeats containing the ‘stretched U–U wobble’: implications for myotonic dystrophy

11 May 2009

Abstract excerpt

Tracks containing CUG repeats are abundant in human gene transcripts. Their biological role includes modulation of pre-mRNA splicing, mRNA transport and regulation of translation. Expanded forms of CUG runs are associated with pathogenesis of several neurodegenerative diseases, including myotonic dystrophy type 1. We have analysed two crystal structures of RNA duplexes containing the CUG repeats: G(CUG)(2)C and...

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PMID: 19433512
DOI: 10.1093/nar/gkp350

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