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CUG Repeats Present in Myotonin Kinase RNA Form Metastable “Slippery” Hairpins

1 Dec 1997

Abstract excerpt

We show that CUG repeats form "slippery" hairpins in their natural sequence context of the myotonin kinase gene transcript. This novel type of RNA structure is characterized by strong S1 and T1 nuclease and lead cleavages in the terminal loop and by mild lead cleavages in the hairpin stem. The latter effect indicates a relaxed metastable structure of the stem. (CUG)5 repeats do not form any detectable secondary...

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PMID: 9388259
DOI: 10.1074/jbc.272.49.31079

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