Article
Evaluation of the pathogenesis of decreasing CD4(+) T cell counts in human immunodeficiency virus type 1-infected patients receiving successfully suppressive antiretroviral therapy.
The Journal of infectious diseases - 1 Jun 2009
Nies-Kraske Elizabeth, Schacker Timothy W, Condoluci David, Orenstein Jan, Brenchley Jason, Fox Cecil, Daucher Marybeth, Dewar Robin, Urban Elizabeth, Hill Brenna, Guenaga Javier, Hoover Shelley, Maldarelli Frank, Hallahan Claire W, Horn Judith, Kottilil Shyamasundaran, Chun Tae-Wook, Folino Marlene, Palmer Sara, Wiegand Ann, O'Shea M Angeline, Metcalf Julia A, Douek Daniel C, Coffin John, Haase Ashley, Fauci Anthony S, Dybul Mark
Abstract excerpt
Most human immunodeficiency virus (HIV)-infected individuals experience increases in peripheral CD4(+) T cell counts with suppressive antiretroviral therapy (ART) that achieves plasma HIV RNA levels that are less than the limit of detection. However, some individuals experience decreasing CD4(+) T cell counts despite suppression of plasma viremia. We evaluated 4 patients with a history of CD4(+) T cell decline...
Topics
- CD4 Lymphocyte Count
- CD4-Positive T-Lymphocytes
- DNA, Viral
- HIV Infections
- HIV-1
- Humans
- In Situ Hybridization