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Article

BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells

16 May 2013

Abstract excerpt

The purine analog fludarabine (Fd) is an essential therapeutic for chronic lymphocytic leukemia (CLL). Innate or acquired resistance to Fd is a significant clinical problem and is largely mediated by increased expression of BCL-2 family members. The antiapoptotic BCL-2 family proteins inhibit both apoptosis and autophagy, therefore, downregulation of antiapoptotic BCL-2 family proteins and enhanced autophagy must...

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PMID: 23681223
DOI: 10.1038/cddis.2013.155

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