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Article

APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2015

Cagnetta Antonia, Caffa Irene, Acharya Chirag, Soncini Debora, Acharya Prakrati, Adamia Sophia, Pierri Ivana, Bergamaschi Micaela, Garuti Anna, Fraternali Giulio, Mastracci Luca, Provenzani Alessandro, Zucal Chiara, Damonte Gianluca, Salis Annalisa, Montecucco Fabrizio, Patrone Franco, Ballestrero Alberto, Bruzzone Santina, Gobbi Marco, Nencioni Alessio, Cea Michele

Abstract excerpt

PURPOSE: The nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, APO866, has been previously shown to have antileukemic activity in preclinical models, but its cytotoxicity in primary leukemia cells is frequently limited. The success of current antileukemic treatments is reduced by the occu...

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Source

Identifiers

PMID: 25964294
DOI: 10.1158/1078-0432.CCR-14-3023

Genes

NAMPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25964294-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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