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Evaluation and analysis of novel germline variants in ethanol metabolism pathway genes predisposition to liver disease.

Gene - 15 Jul 2023

Das Partha Pratim, Jyoti Kalita Manash, Jyoti Talukdar Anjan, Mohd Khan Faraz, Dutta Kalpajit, Kalita Simanta, Goswami Nabajyoti, Hazarika Gautam, Samudrala Gourinath, Ghaznavi Idris Mohammed, Dutta Sangit, Medhi Subhash

Abstract excerpt

The pathogenetic events of liver disease are seemingly determined by factors linked to ethanol metabolism. The variations in genes encoding enzymes of the ethanol metabolic pathway can influence exposure to alcohol and thus may act as risk factors for the development of liver disease. The present study aimed to understand the genetic aspect of germline variations in ethanol metabolic pathway genes in two major...

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PMID: 37150234
DOI: 10.1016/j.gene.2023.147451

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