Effect of expression level on immune responses to recombinant oral Salmonella enterica serovar Typhimurium vaccines.

Abstract excerpt

Live, attenuated Salmonella has been used to express heterologous antigens for development of oral vaccines. Often, expression must be regulated because of deleterious effects on the Salmonella vector. The effect of varying expression levels on immune response parameters has not been well defined. In this study we introduced mutations in the -10 region of the trc promoter in the expression plasmid to generate...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adhesins, Bacterial
• Share to Administration, Oral
• Share to Antibodies, Bacterial