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Article

High-throughput sequencing of kDNA amplicons for the analysis of Leishmania minicircles and identification of Neotropical species.

Parasitology - 1 Apr 2018

Kocher Arthur, Valière Sophie, Bañuls Anne-Laure, Murienne Jérôme

Abstract excerpt

Leishmania kinetoplast DNA contains thousands of small circular molecules referred to as kinetoplast DNA (kDNA) minicercles. kDNA minicircles are the preferred targets for sensitive Leishmania detection, because they are present in high copy number and contain conserved sequence blocks in which polymerase chain reaction (PCR) primers can be designed. On the other hand, the heterogenic nature of minicircle...

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PMID: 29144208
DOI: 10.1017/S0031182017002013

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