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Evolutionary divergent kinetoplast genome structure and RNA editing patterns in the trypanosomatid Vickermania

9 Apr 2025

Abstract excerpt

The trypanosomatid flagellates possess in their single mitochondrion a highly complex kinetoplast (k)DNA, which is composed of interlocked circular molecules of two types. Dozens of maxicircles represent a classical mitochondrial genome, and thousands of minicircles encode guide (g)RNAs, which direct the processive and essential uridine insertion/deletion messenger RNA (mRNA) editing of maxicircle transcripts....

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PMID: 40203041
DOI: 10.1073/pnas.2426887122

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