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Article

Variations at a quantitative trait locus (QTL) affect development of behavior in lead-exposed Drosophila melanogaster.

Neurotoxicology - 1 Mar 2009

Hirsch Helmut V B, Possidente Debra, Averill Sarah, Despain Tamira Palmetto, Buytkins Joel, Thomas Valerie, Goebel W Paul, Shipp-Hilts Asante, Wilson Diane, Hollocher Kurt, Possidente Bernard, Lnenicka Greg, Ruden Douglas M

Abstract excerpt

We developed Drosophila melanogaster as a model to study correlated behavioral, neuronal and genetic effects of the neurotoxin lead, known to affect cognitive and behavioral development in children. We showed that, as in vertebrates, lead affects both synaptic development and complex behaviors (courtship, fecundity, locomotor activity) in Drosophila. By assessing differential behavioral responses to developmental...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19428504
DOI: 10.1016/j.neuro.2009.01.004
PMCID: PMC3734858

Genes

ADA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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