Article
TP53 mutation signature supports involvement of aristolochic acid in the aetiology of endemic nephropathy-associated tumours.
International journal of cancer - 15 Feb 2009
Nedelko Tatiana, Arlt Volker M, Phillips David H, Hollstein Monica
Abstract excerpt
The proposal has been put forward that the primary cause of Balkan endemic nephropathy (BEN) is exposure to food crops contaminated with seeds of Aristolochia spp, which contain high levels of aristolochic acids (AA). Recently, tumour DNA samples from patients with BEN were found to harbour principally A to T mutations in the TP53 tumour suppressor gene (Grollman et al., Proc Natl Acad Sci USA 2007;104:12129-34)....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.