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Article

A phagocytosis mutant of Entamoeba histolytica is less virulent due to deficient proteinase expression and release.

Experimental parasitology - 1 Feb 2007

Hirata Ken K, Que Xuchu, Melendez-Lopez Samuel G, Debnath Anjan, Myers Simona, Herdman D Scott, Orozco Esther, Bhattacharya Alok, McKerrow James H, Reed Sharon L

Abstract excerpt

Cysteine proteinases are key virulence factors of Entamoeba histolytica that are released during the process of invasion. We used a chemical mutant of E. histolytica strain HM-1:IMSS, clone L6, which is deficient in virulence, phagocytosis, and cysteine proteinase activity to help define the mech...

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Source

Identifiers

PMID: 16987516
DOI: 10.1016/j.exppara.2006.08.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16987516-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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