Article
A genome-wide search for non-UGT1A1 markers associated with unconjugated bilirubin level reveals significant association with a polymorphic marker near a gene of the nucleoporin family.
Annals of human genetics - 1 Jan 2012
Datta Shalini, Chowdhury Abhijit, Ghosh Malay, Das Kaushik, Jha Pankaj, Colah Roshan, Mukerji Mitali, Majumder Partha P
Abstract excerpt
Variants in the UGT1A1 gene and its promoter are known to determine levels of unconjugated bilirubin (UCB), but do not explain all cases of unconjugated hyperbilirubinemia. To discover associations with variants in genes other than UGT1A1, we undertook a genome-wide association study. We recruited 200 participants to cover the entire range of quantitative variation in UCB level. The data set -- after data...
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