Article
The genetics of Parkinson's syndromes: a critical review.
Current opinion in genetics & development - 1 Jun 2009
Hardy John, Lewis Patrick, Revesz Tamas, Lees Andrew, Paisan-Ruiz Coro
Abstract excerpt
Genetic analysis has identified many loci designated as PARK loci (OMIM #168600). Many of these loci do not refer to idiopathic Parkinson's disease which is characterized by Lewy body pathology, but rather to clinical parkinsonisms. In this review, besides reviewing the genetic of the disorder, we argue that this designation is misleading and that if we seek to understand the pathogenesis, we should study the...
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