Article
Detection of disease-associated deletions in case-control studies using SNP genotypes with application to rheumatoid arthritis.
Human genetics - 1 Aug 2009
Wu Chih-Chieh, Shete Sanjay, Chen Wei V, Peng Bo, Lee Annette T, Ma Jianzhong, Gregersen Peter K, Amos Christopher I
Abstract excerpt
Genomic deletions have long been known to play a causative role in microdeletion syndromes. Recent whole-genome genetic studies have shown that deletions can increase the risk for several psychiatric disorders, suggesting that genomic deletions play an important role in the genetic basis of complex traits. However, the association between genomic deletions and common, complex diseases has not yet been...
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