Article
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.
PLoS genetics - 1 Jun 2009
Raychaudhuri Soumya, Plenge Robert M, Rossin Elizabeth J, Ng Aylwin C Y, Purcell Shaun M, Sklar Pamela, Scolnick Edward M, Xavier Ramnik J, Altshuler David, Daly Mark J
Abstract excerpt
Translating a set of disease regions into insight about pathogenic mechanisms requires not only the ability to identify the key disease genes within them, but also the biological relationships among those key genes. Here we describe a statistical method, Gene Relationships Among Implicated Loci (GRAIL), that takes a list of disease regions and automatically assesses the degree of relatedness of implicated genes...
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