Article
A high-resolution survey of deletion polymorphism in the human genome.
Nature genetics - 1 Jan 2006
Conrad Donald F, Andrews T Daniel, Carter Nigel P, Hurles Matthew E, Pritchard Jonathan K
Abstract excerpt
Recent work has shown that copy number polymorphism is an important class of genetic variation in human genomes. Here we report a new method that uses SNP genotype data from parent-offspring trios to identify polymorphic deletions. We applied this method to data from the International HapMap Project to produce the first high-resolution population surveys of deletion polymorphism. Approximately 100 of these...
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