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Article

Bacteria-Induced Uroplakin Signaling Mediates Bladder Response to Infection

30 Apr 2009

Abstract excerpt

Urinary tract infections are the second most common infectious disease in humans and are predominantly caused by uropathogenic E. coli (UPEC). A majority of UPEC isolates express the type 1 pilus adhesin, FimH, and cell culture and murine studies demonstrate that FimH is involved in invasion and apoptosis of urothelial cells. FimH initiates bladder pathology by binding to the uroplakin receptor complex, but the...

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PMID: 19412341
DOI: 10.1371/journal.ppat.1000415

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